A mutated bird flu virus spreads across the world. As panic spreads, the governor of Virginia quarantines neighborhoods where cases have cropped up, and federal officials confess they have no vaccine and scant supplies of antiviral drugs. Major socioeconomic disruption sets in, with shortages of food and medical supplies, power outages, and riots in the streets of New York.
The film begins with scenes of life in Wyoming Territory, where new settlers join the cattle business by finding stray, unbranded cattle, called "mavericks", on public land. The narrator explains that established ranchers use the "Maverick Act" against the settlers, while "sharp-witted men" take advantage of the resulting conflict. After this introduction, Jim Averell (Bishop) is shown exhorting settlers to elect him governor to defend them against cattle barons such as Reece Duncan (Scourby).
In Pre-England Britain, before the birth of King Arthur, Merlin serves under King Vortigern. Soon after Vortigern's coronation, fire-breathing dragons land in Britain, setting fire to buildings and eating its inhabitants. The dragons threaten the existence of Britain, and Vortigern instructs Merlin to lead an army against the dragons, ordering his best generals, Hengist and Uther to aid Merlin.
Melvin Van Peebles is the film's narrator, introducing the film's main characters. Yves Malmaison (Richard Fancy) is a world-famous French fashion designer. A flaming homosexual with a preference for red hair, he once experimented with an American woman, and thus he has a son, Sebastian (Ilan Mitchell-Smith).
Nate and Skylar, sons of sheriff Bloom Towne, are involved in the accidental death of Mayor Cavanaugh's son Dick in a hunting accident. Older brother Nate fired the deadly shot, but to protect him, younger Skylar, still a minor, takes the blame. Owning most of the town's businesses, the Cavanaugh family itself is wealthy and influential.
The president of the United States is kidnapped during a charity event. The kidnapping was orchestrated by his chief of staff to boost the president's popularity for the upcoming elections. However, one of the kidnappers decides the opportunity is too good to pass up and turns it into a real kidnapping while a fellow kidnapper is determined to foil his plan.
Stock car racer Jo Jo Quillico goes to Europe after an accident. He is hired by a race-car tycoon to be runner-up for a more experienced racer on the European circuit, working with his mechanic Charlie. However, in his first race, Jo Jo can't help winning.
A town is attacked by a deadly creature, it can only be stopped with the Dragon Blade. The one person who knows where the blade is won't tell Lang, and even if he did, untold peril will fall on anyone who dares to find this legendary weapon.
Fu Manchu attempts to conquer the world by acquiring the sceptre of Genghis Khan, which will unite the people of Asia under his rule. Allan Parker allies himself with the traditional British literary nemeses of Fu Manchu, Sir Denis Nayland Smith and his associate, Dr. Flinders Petrie after his father is kidnapped and killed by Fu Manchu's dacoits.
In California, a homeless and mentally ill man, Rex, comes to believe he is a gunfighter from the American Old West, and heads for Los Angeles. While travelling, he begins a murder spree, and his victims include police officers. He becomes fixated on Los Angeles police officer John Shepard, who is in the news after killing a drug dealer in a shootout, and news anchor Maggie Hewitt, who broke the story.
Joe Nation wants to go viral on YouTube and reach Internet fame. But things take a turn for the worse when he mistakenly hires Bob Thunder, a cold-blooded killer, to help him.
Adventurer Al Colby is persuaded by Anna Luz and her antiquities-collector husband Thomas Berrien to help them smuggle a parcel into Mexico where its true value can be ascertained. Warned that a man named Jefferson, who is traveling on the same freighter, might try to steal the parcel, Colby forms a partnership with Jefferson following Berrien's fatal heart attack aboard the ship. Jefferson betrays and shoots Colby, but Colby saves himself and the rare documents in time.
In Civil War-era Southern Missouri, Dr. Maggie McCullough travels to the aid of her ailing aunt, Annie, the town's madame, in the lovely community of Sweetwater. With all of the men away at war, Maggie coordinates a truce between Aunt Annie's girls and the respectable women of the town.
Eric Desmond is an amateur marshal in the wilderness of Alaska who has to deal with a homicidal trapper Ben Corbett, his fellow trappers and a greedy politician.
During the siege of Richmond, Virginia, in the American Civil War, POW Capt. Cyrus Harding escapes from his Confederate captors in a rather unusual way – by hijacking an observation balloon. In his escape, Harding is accompanied by sailor Pencroft, his nephew Bert, writer Gideon, loyal soldier Neb, and a dog.
A crooked lawyer brings together some of the clients he's gotten off and schemes to rob a bank vault. However, after the robbery, he discovers that the "goods" he's stolen is actually a top-secret microchip that foreign powers are after, and they will stop at nothing to get it.
Detective Bobby Corcoran and his partner, Detective Larson, are on the hunt for a vicious serial killer. As the murderous villain stalks the city streets leaving carnage in his wake, Corcoran begins to experience blackouts and sudden fits of anger. As the detectives pursue the case, they uncover evidence suggesting that one of them may be responsible for the mysterious deaths.
While flying his helicopter, Harry Walker observes an armed robbery of an armored car at the Zion's Bank in downtown Salt Lake City in which bearded men gun down the guards and grab a canvas sack of currency, then grab a female hostage and shove her into their getaway car. Over the radio, Walker reports what he has seen to his old military commander McAndrew. Walker then pursues the car, while McAndrew informs him that fingerprints have identified two of the robbers as former Marines who served in Vietnam and they surmise that the chopper pilot is similarly experienced.
Lawrence Hammer (Lowe) and Dean Mazzoli (Hansen) are two Naval Officers undergoing the rigorous and demanding Navy BUD/s training program. Both men quest to become Navy SEALs. During the training Hammer is shown as cocky and not a true team player.
Three sisters abandoned by their father learn that he has died in prison and left them clues to money hidden from a robbery. The problem is that a former deputy involved in the robbery is also seeking the money.
Before his capture, Geronimo had cursed white men, causing people to become zombies. Later, at a house in a small town, a man named Ben Goodman (Brian Posehn) acts suspiciously. Ben proceeds to attack and eat his wife and daughter's brains.