Mary Smith (Merle Oberon), daughter of presidential hopeful Horace Smith (Henry Kolker), has lived a cloistered life free of any scandal. Although she supports his political aspirations, she longs for a life of her own. Believing she needs some excitement in her life, Mary's free-spirited Uncle Hannibal (Harry Davenport) takes her dancing at a nightclub, which the police raid for gambling.
Christine Riverton Duncan attempts to play matchmaker for her lovelorn friend Ellen by pursuing Douglas J. Morrissen, Jr., the man whom Ellen loves, all the way to Idaho. While there, Christine decides to play a joke on Douglas.
The film follows Alice (Saskia Axten) a young student who stumbles into a bizarre version of London after her night with a newfound lover, Rabbit (Elijah Rowen) appears to suddenly have never happened. The night in question just happens to be the evening of the UK's 2016 referendum on EU membership. The film itself periodically shifts to different layers of narrative, from the Alice in Wonderland adapting narrative of Alice's search for Rabbit in an upside-down version of London, to a satirical "real world" scenario, showing philosophers and the "director" (played by director Adam Donen) reacting to the film they are planning.
"Disaster '76", the latest disaster film, is playing at The Alamo, a drive-in theater in a small Texas town. The night brings together a young couple, two rival youth gangs, a pair of thieves planning to rob the drive-in, a nervous doctor and a host of other characters.
Anne Leeds is a school teacher with only four weeks of experience. She takes a part-time job as a secretary to an ex-bootlegger and horse-playing gambler by the name of Rocco. He's a Broadway nightclub owner with a heart of gold who falls in love with Anne.
Midwest native Billy Collier is an aspiring photographer in Los Angeles, who has had little artistic success and much romantic frustration. While out for coffee with his roommate named Georgiana, he comes up with the idea of recreating iconic screen kisses from Hollywood movies. That night at a party, Billy's friend Perry agrees to finance the project.
Homer Flagg is a railroad worker in the small town of Desert Hole, New Mexico. His big dream in life is to visit New York City while he is young. One day he finds an abandoned automobile at an old atomic proving ground.
Ben Stein introduces the film as a long-lost film from the 1980s, so a lot of the jokes are now outdated in 2006. As the Gunderson family sets out on a cross-country road trip to their new home, boyishly handsome Charlie, blossoming dancer Lori, and highly intelligent Max all have their own ideas of what life will be like in their new town. When Charlie is singled out as the least popular senior on the very first day of school, kindly outcast Billie amiably agrees to show him the ropes and provide him with an illuminating crash course in the clique system.
In Texas in 1981, Lorna (Gina Gershon) invites her friend Tiny (Kelli Giddish) over to talk about the recent bank robbery at the Waldorf Savings & Loan in nearby Red County. Tiny arrives to find Lorna's husband Dale (Val Kilmer) unconscious on the living room floor, Lorna having whacked him over the head with a skillet, and Lorna tells her that she knows that he was the bank robber. Tiny explains that just because Dale used to rob convenience stores doesn't make him fit to be a bank robber, but Lorna insists.
Carol Cartman is a conceited sensationalist talk show host. She is cynical, selfish, and generally treats her employees with cold contempt. She has been coached by her late Aunt Marla to behave this way, and holds true to it; she despises Christmas and values hardly anyone.
Harry Moulton Pulham Jr. (Robert Young) is a conservative, middle-aged Boston businessman, set in a precise daily routine. He has a proper wife, Kay (Ruth Hussey), with whom he has settled into a comfortable if passionless relationship.
A barrel of radioactive waste is lost out in the woods, leading to some demented rednecks finding it, and using it as part of their still. Everybody who drinks the liquor they produced turns into zombies.
Bernadette and Bill are a bickering couple from Beverly Hills. One day, a stranger wanders onto their property and they mistake him for an exterminator. The man, who calls himself Bone, takes the couple hostage, intending to rob them.
Imprisoned for involuntary manslaughter during a carjacking, Travis Clyde Tuckton is released from prison in 2003, and shacks up with his disabled grandfather, Jake Martin, in the old shoemaker's secluded West Virginia home. Jake elects to teach Travis everything he knows, starting with the family tradition of "headers"; the act of having sex with a hole drilled into a person's skull. Travis picks up a hitchhiker, and as Jake supervises, loses his "head humping" virginity to her.
Rita La Punta (Marília Pêra) leads a gang of Brazilian juvenile delinquents in an attempt to seize control of New York's Lower East Side's illegal drug trade from a Puerto Rican gang.
The Pilgrim, an escaped convict, steals a minister's clothes to replace his prison uniform. At a train station, he encounters an eloping couple who want him to marry them. The woman's father shows up and takes her away.
The Stooges are inept repairmen who undertake the task of repairing the doorbell of a sprawling residence, unaware that it serves as the clandestine headquarters for a group of Nazi agents, led by the formidable Hans. The agents are preparing to carry out sabotage involving a remote submarine. Meanwhile, the Stooges's energetic but clueless efforts to repair the doorbell wreak havoc within the premises, causing extensive damage to the house's infrastructure and disrupting the city's telephone wire system.
Elle and Joy are two sisters apart by two years. The two are singers and are living together away from the city and making do with the new life they have chosen.
Gunther Schmidt (Thomas Gottschalk) is a young, eccentric East German inventor who (like many others) attempts to flee across the border to the West using his inventions, but constantly meets with failure. Finally, he constructs a gadget which actually works: a modified Trabant ("Trabbi") with a motor running on turnip juice, making it ultimately environmental but still capable of attaining a speed of up to 250 km/h. But by the time his invention is perfected, East and West Germany are reunited, rendering the Trabbi's role as an escape vehicle obsolete.
Former ballplayer "Coop" (Dailey) is working as a peanut vendor at the ballpark of a struggling major league club, the Bisons. He has passed on his love of the game to his son Christie (Chapin), but after sneaking his son into the game one too many times, he is fired from his job. Christie ingratiates himself with the former owner's niece (Bancroft) and gets his father's job back as well as a position as batboy for himself.