The film is about two orphans - Mac Ramsey and Li Ann Tsei who have spent their life living with the Tang family - a ruthless Chinese organized crime syndicate. Mac and Li Ann were taken in by the Tang Godfather and have formed a close friendship with his son Michael. When they grow up, Li Ann is betrothed to Michael, but falls in love with Mac so the two scheme to steal money from the Tang family and run off to start a new life.
Taking advantage of West German bank privacy laws, several criminals use safe deposit boxes in a Hamburg bank to store large amounts of illicit cash. These include Las Vegas mobster and attorney Mr. North, a ruthless drug smuggler known as the Candy Man, and a crooked overbearing U.S.
New Orleans narcotics detective Anthony Stowe (Jean-Claude Van Damme) is a heroin addict who is teetering on the edge of oblivion, and he could not care less. At the moment, he is trying to bring down his former partner Gabriel Callahan (Stephen Rea), who has become a drug kingpin. Callahan is trying to, and slowly succeeding at, taking over the New Orleans underworld.
As the movie opens, Sherlock is in pursuit of the criminal Professor Moriarty (Vincent D'Onofrio) and apparently shoots him to death. His body cannot be found, however, as it falls in a sewer. After this incident, Holmes gains notoriety with the press and the police for his apparent killing of Moriarty, and meets Dr.
Dr. Watson is working as resident physician at Musgrave Manor in Northumberland, a stately home which is also used as a hospital for a number of servicemen suffering from shell shock. When Sally Musgrave displays her feelings for one of the wounded American fighter pilots, Captain Pat Vickery, who is currently recovering at the family estate, her brothers Geoffrey and Phillip are quick to show their dismay.
A phantom cargo ship is found adrift at sea in a storm in the English Channel by a marine salvage team aboard the Sea Witch. She is the steamship Mary Deare, out of Hong Kong. John Sands boards it hoping to claim it for himself and his partner, Mike, but finds former First Officer Gideon Patch alone but still in command.
A young snooker player is helped by a local gangster and a veteran Chinese pool champion to break free from a world of crime and reach the glittering lights of Beijing to play in a prestigious Chinese snooker tournament that could save his life. It has been described as "Rocky with a snooker cue".
An armed robbery involving criminal Stone goes wrong when an inexperienced getaway driver accidentally causes the death of a nine-year-old girl in a car crash. The girl's millionaire father arranges for a bounty hunter, Costello, to kill the three criminals involved, including Stone. Stone flees to England where he stays with an old friend, Abbatt.
Harry Spikes is an aging bank robber of the fading Old West. Injured and near death, he is found and mended back to health by three impressionable youths who are lifelong friends—Wil Young, Tod Hayhew, and Les Richter. They refuse any payment from Spikes for their efforts, and when he's healed, he leaves saying he won't forget their kindness.
The film opens up with an armored truck coming across a car accident in the middle of a road. The driver finds this suspicious and prepares to drive off, but the truck is suddenly attacked by masked robbers. The driver tries to make a break for it, but his partner is revealed to be in on the heist.
In a house at Cherry Tree Lane, middle-aged couple Christine (Rachael Blake) and Mike (Tom Butcher) are eating dinner while their son, Sebastian, is out at football practice. When the doorbell rings and Christine goes to answer it, they’re attacked by three youths, Rian (Jumayn Hunter), Asad (Ashley Chin), and Teddy (Sonny Muslim), who hold them both hostage in their front room. Knowing Sebastian will be returning, the group waits so that they can get revenge on him for grassing on Rian's cousin and getting the latter sent to prison; Teddy leaves with Mike's credit cards to find a cash machine.
The film opens with Eddie Macon escaping from prison. The first half of the film then relates the backstory through a series of flashbacks. Eddie is a man that has relocated from Florida to Texas in order to better provide for his wife Chris and their young son Bobby, who suffers from a blood disorder.
Travis McGee and his close friend Meyer are fishing underneath a bridge in their coastal Florida home. To their shock a young woman is thrown off the bridge; she is bound and a foot is strapped to a dumbbell with an ankle adapter. Travis dives in and saves her, learning her name is Vangie.
Former US Army lieutenant Jason Higgs, after becoming a black militant during the 1960s Black Revolutionary Movement, is wounded as he pulls a payroll heist to help imprisoned brothers, and has to hide from the police. Social worker Cathy Ellis falls in love with Higgs while helping him elude capture.
The story is told in flashback from Death Row as Ronnie Jackson (Bob Hope) relates to a group of reporters the events that led to his murder conviction. In San Francisco, Ronnie works as a child photographer who dreams of being a private detective like his office neighbor Sam McCloud (Alan Ladd). One day, he is mistaken for McCloud by mysterious woman in distress, Carlotta Montay (Dorothy Lamour), who claims that her wheelchair-using husband was kidnapped.
The alien criminal from the first movie is dead, but he left a few eggs which are hatching now. It is explained that on the alien's homeworld, evolution took two parallel paths: half of their race became violent criminals who live only for pleasure (the squid-like alien form briefly glimpsed in the first film), and the other half evolved beyond their base desires and even physical bodies, becoming creatures of pure energy. Alhague, a good alien from the first movie, has been inhabiting Tom Beck's body (played now by Michael Welden).
Out-of-work scrounger Robert Martin lives with his dysfunctional family (long-suffering wife Angie, accident-prone son Little Bob, and pregnant 14-year-old daughter Katie) in a shabby house in Hatfield, next door to the Galleria Shopping Centre above the A1, about 25 miles north of London. Competition addict Robert dreams of winning a holiday for his family to a dream island. It turns out to be the Isle of Man, but he fails to win the competition.
When veteran cab driver Pop Riley of the Independent Cab Company refuses to surrender his prime location outside a cafe where his daughter works, his taxicab is wrecked by a henchman from the rival Consolidated Cab Company, which is trying to dominate the taxi industry. When he sees that his cab has been destroyed, Pop shoots and kills the man. He is sentenced to prison, where he soon dies of poor health.
Bobby mentors his young cousin, Seamus, into a life of drugs and crime soon after Seamus emigrates from Dublin, Ireland. Bright, conscientious, but notably naive, Seamus finds himself unable to get used to the spontaneous dangers and recklessness of his new life in the United States. Seamus commits a hate crime on an African American youth who had crossed the racial boundary around Charlestown in the 1990s.
Master criminal Giles Conover (Miles Mander) steals the famous "Borgia Pearl" from the Royal Regent Museum under the very nose of Sherlock Holmes and Dr. Watson, but when Mander is caught the pearl is not found on him and he is released. Later, Holmes hears of an apparently motiveless murder.
Broadcast in the year 2008, the film is presented in a TV documentary style format, combining talking head interviews, news coverage clips and video surveillance footage surrounding the assassination of U.S. president George W. Bush in Chicago around a year earlier on 19 October 2007.