A ship named 'African Goddess' from Somalia, Africa docks at Mumbai, India. As the workers disembark and collect their pay, one is seen to be ill and injured on the elbow, that worker's name is Rajiv, one of the other worker asks the manager about Rajiv's whereabouts and gets to know that while leaving Somalia, a 'Mad woman' had bitten him. Behind the manager, the radio can be heard telecasting a news saying that 'It is not yet known about the reasons of the acts of cannibalism in Africa'.
The film opens with another gym killing, yet another in a killing spree by an unknown person, who only attacks local spas and gyms. Among those investigating is Mike "Sully" Sullivan, Wyznowski and Yamata at the crime scene, Sully spots a mysterious man leaving, and does not believe him to be one of the police force. They find that there was one sole survivor, a young woman who hid in her locker, and is currently at the hospital, under heavy medication.
Caleb Kilgore (Tony Todd) is a farmer who has been obsessed with a scarecrow that killed his father (Michael Flowers Jr) years ago. Two friends looking to join a fraternity are given the initiation task of stealing the scarecrow from Caleb's field. After his father's murder, Caleb had caught the scarecrow and tied it down so that it could never escape.
A camouflage-clad serial killer has begun mysteriously killing the members of the school's majorette squad under the guise of "saving their souls" before they reach adulthood. Local Sheriff Braden and a federal agent investigate the killings. Pregnant teenager Nicole Hendricks is among the first victims, who is attacked and murdered alongside Tommy Harvack, a male acquaintance.
A girl, Heather Dhal, runs through the woods, pursued by an unknown assailant. She is caught and her hand, which is wearing a ring, is chopped off and left in the woods while her body is dragged away. Twenty years later, recently orphaned teen Jordan and her boyfriend Larry go to a party.
As his father works on a tractor, young Matthew turns it on and kills him with it, damaging his own left hand in the process. Matthew is subsequently placed in a psychiatric hospital, and his mangled limb is replaced with a hook. At the age of eighteen, Matthew is released from the asylum, and returns home, discovering that in his absence his mother has married a neighbor named Mack Parsons.
Dr. Laurience, a once-respectable scientist, begins to research the origins of the mind and soul in an isolated manor house, aided only by the promising surgeon Clare Wyatt and a wheelchair-using confederate named Clayton. The scientific community rejects his theories and Laurience risks losing everything for which he has worked so obsessively.
A message indicates that the following amateur footage was recovered from a stolen laptop. Gus, a metal detector enthusiast, takes his girlfriend Sally and her videographer friend Jake with him to search for buried treasure in Suffolk, England. Gus discourages them from taking many supplies, as they will not be gone long.
Two siblings lure married men from a party line so their disturbed brother can slit their throats with a straight razor. A detective investigates with his captain.
Robbin Stanley, a young hitchhiker, left stranded after a car crash and wandering on a California beach, is taken in by Jason Henry, a photographer and Korean War veteran, who lives in a nearby beach front house with his sister Grace. After Jason confides that Grace has some mental problems, Robbin soon begins to suspect that the opposite applies and that the mansion is home to some very strange goings-on.
In 1969, ten-year-old Frank Sears is confronted by his hysterical mother Eleanore, who carves the message "S3 V12" into the palms of his hands with a pencil and warns him to never forget her warning before murdering her husband and committing suicide. In the present, Frank is now a biology teacher haunted by the night his mother died. Having tried to forget about her warnings, he conducted an internet search that led him to drive all the way from New Jersey to the town of Bennell, New Mexico in an attempt to visit the Army base Fort Lambert.
While on board the space ship Nautilus, an astronaut turns into an Alien-like monster after being infected by alien spores. When the ship crash lands in Florida, the monster goes on a killing rampage.
Phillip Reynolds is a widowed, successful plastic surgeon and a charismatic sociopath. After he sees his daughter, Heather, making love to her boyfriend, he kills the boyfriend and stages the scene to appear like an accident. Heather witnesses this from afar and runs away from home in terror.
After receiving a warning not to come to their family lake house in Maine, siblings Lyla and Ed stage an intervention for their brother, Martin, a dishonorably discharged veteran who believes the military has experimented on him. When they arrive, they find that he has descended into apparent paranoid psychosis and claims to have trapped a monster in the basement. Martin explains that he found a pod while hunting in the woods and believes it to be part of a government conspiracy to create artificial, inanimate assassins.
In April 1987, two North Americans disappeared in the West Australian desert on a 4WD holiday. They were never seen alive again. Their abandoned vehicles and unused supplies were found in sand dunes near an Aboriginal sacred site less than an hour away from the closest town.
As a zombie apocalypse begins, a group of zombies attack the residents in a house. When the family recognizes one of the zombies as a family member, the zombie is shocked back to his senses and decides to protect his family.
Harry West (Norman Willis) discovers gold in the idol worshipped by a jungle voodoo tribe in Bantalaya, a French-owned jungle colony. Harry enlists a pair of treasure hunters from the United States, one of them being the beautiful but ruthless Marilyn Blanchard (Marla English). Hoping to take the treasure for themselves, Marilyn murders Harry and steals his map.
Michelle Rosen, an introverted and insecure high school student, is approached at lunch by popular jock Aaron Cussler, who invites Michelle to a party he is throwing. Charmed by Aaron, Michelle goes to the gathering, where she makes out with Aaron (to the annoyance of Aaron's occasional girlfriend Debbie) and befriends another student named Wendy, a formerly overweight outcast who is now a member of Debbie and Aaron's clique. As the night progresses, Aaron and two of his friends, Steve (Wendy's boyfriend) and Jake, get Michelle drunk, and slip her a roofie.
Dylan White (Callum Blue) has no memory of his life prior to waking up from a coma. He has created an entirely new identity as an ordinary cook in Baton Rouge. Things are normal for Dylan until he begins to experience horrifying visions, forcing him to look further to discover who he was before he lost his memory.
Chris is an archaeologist who has vivid nightmares about the murder of his parents and little sister during his childhood. The family had been living in the ruins of a Yugoslavian monastery so that his father could search for the tomb of Prince Elok, a ten year old prince who was obsessed with torture and worshiped a Slavic demon. The murders were believed to have been committed by a workman named Roman Hart, who was later institutionalized at a mental hospital local to the site.
