The promotional film begins with framing device, wherein Scorsese, playing himself, describing how he discovered three and a half pages of an unproduced Alfred Hitchcock film, "The Key to Reserva". As part of this film preservation work he plans to film the script as Hitchcock would have filmed it. The film, which contains no dialogue, shows Roger Thornberry arriving at a box seat during an orchestra performance.
After a fatal car crash in Lordsburg, New Mexico, investigators find a mysterious machine component that they turn over to the nearby Los Alamos National Laboratory for identification. Scientists there declare that it is one component of an advanced portable nuclear weapon designed by an unknown, presumably hostile power. The discovery prompts Paul Reagan (Richard Denning), chief of the Security Investigation Division (SID), to send agent John Williams (John Ireland) to investigate the source of these components and to prevent them from being assembled into a functioning weapon.
Hired to interview and write a book about Margaret Drake, biographer Shellane Victor comes to the Drake estate, where family members notice her resemblance to their deceased relative, Yvette. The Drakes believe that Yvette, who died after falling off of a cliff, is haunting the mansion.
Having been sent a picture of her husband, a war hero reported missing in action in France, Meg Elgin, now engaged to Geoffrey Leavitt, is led to believe he is still alive and arranges a meeting at a London railway station. When she arrives there with the police accompanying her, she catches sight of a man in the distance wearing an old coat of her husband's. When he is pursued and captured, he turns out to be Duds Morrison, a former soldier and out-of-work actor recently let out of prison.
When his mother dies, Brian Carter is surprised to learn that he has inherited The Sanctuary, home to her controversial experimental addiction treatment center. Having previously believed that the building burned to the ground years ago, Brian travels there with a group of friends and meets Haley, a mysterious friend of his mother, who acts as their guide through the impressive, monastery-like building. During their tour it becomes clear that something sinister lies beneath the surface.
In England in the Middle Ages, a dragon decimates a town, and six knights vow to kill the creature in its lair. In the ensuing fight, the dragon shoots a fireball at the knights' barrels of gunpowder. This causes an explosion and a cave-in which traps the dragon and five of the six knights.
Steve Morgan (Tierney) is a charming sociopath who has just robbed and killed a cinema cashier. Seeking to escape, he hitches a ride to Los Angeles with unsuspecting Jimmy 'Fergie' Ferguson (North). Part way the pair stops at a gas station and picks up two women.
During a race at Monte Carlo, Milos Segora attempts to assassinate Jason Carlyle but shoots an innocent bystander instead. Carlyle and his daughter Ruth flee the scene. Meanwhile, freelance pilot Harry Black is bailed out of prison and released with a warning by Lieutenant Duval.
In the back streets of a tourist town in present-day Cambodia, we find a filthy cinder block room; a bed with soiled sheets; a little girl waits for the next man to use her. Alex, a human trafficking investigator plays the role of her next customer as he negotiates with the pimp for the use of the child. Claire, Alex's wife, is caught up in the flow of her new life in Southeast Asia and her role as a volunteer in an aftercare shelter for rescued girls.
Police lieutenant Nick Ferrone explains the work of bail bondsmen. One such man is Vince Kane, a former police detective who worked with Ferrone. When one of his customers, Claude Brackett, is murdered, Kane investigates, not only because of his curiosity as a former cop; he has also fallen in love with Brackett's widow Lucy, an old flame.
Henrietta O'Dwyer Collins (Barbara Eden), known simply as "Henrie O.", is an investigative journalist called to a mysterious remote island by her old friend Chase Prescott (William Shatner) who fears that someone is trying to kill him. The weekend is filled with intrigue as Henrie O. and all the guests try to figure out who is trying to murder their host.
One of the top computer game designers in the country, Darrin Danver decides to move, with his lovely wife, Bev to Las Vegas and work for Compucom, the leading developer and distributor of computer games worldwide. More than eager to woo their newest arrival, Compucom showers the Danvers, with many luxuries and spoils. Both Darrin and Deb have worked long and hard, and a taste of the "good" life is something they both would not mind savoring for a while.
A physician's death orphans his two adolescent daughters. Their older brother is able to convert some of the doctor's small estate to cash. It is late in the day, and with the banks closed he stores the money in his father's household safe.
Dara Maren is a DEA agent who gets dragged into the seedy underworld of California/Mexico border smuggling in an attempt to protect her younger brother. During a drug deal gone bad, she ends up shooting and killing an undercover ATF agent and is arrested. She's convicted and incarcerated inside a penal colony just outside Tijuana, where the prison officials harvest organs from the inmates.
Louise Henderson is the editor of a respected fashion magazine, but she has a secret career as mastermind of a ring of thieves. With their professional operation as a front, Henderson uses one of her models, Claudia, and a photographer, Raymond Lowe, to steal precious artefacts and jewels. Law enforcement agencies have their suspicions about her, so undercover man Simon Grant is assigned the case.
10 years after Officer Dwayne Hopper’s son disappeared, the last of 14 victims in a string of local unsolved disappearances, his suspicions are aroused by prison inmate Ronald Perkins. Dwayne searches Perkins’ house and discovers a collection of torture videos featuring the missing victims from the past. In a fit of rage, Dwayne kills Perkins.
Luciana is an illegal immigrant to New York City. Phone calls to her family indicate that she is living in hiding due to some past transgression in her native Barcelona for which her mother assures her she's been forgiven but which Luciana does not want to return to face. Due to her undocumented status, Luciana is forced to work menial, cash-pay jobs, such as babysitting and sign waving at a fast food restaurant.
L.A. Detective Sam Dietz (Leo Rossi), struggling to emotionally survive his previous big case (the first Relentless film) is unwillingly paired with a shady FBI agent Kyle Valsone (Ray Sharkey), during a case tracking another serial killer (Miles O'Keeffe), who kills seemingly at random. But every time Dietz gets a lead, Valsone gets in the way and somewhat throws off the investigation.
T.M. Pryor, a former cop, escapes from a prison in Louisiana where he is currently serving out a sentence for killing his wife's lover. Despite the fact that his parole hearing is only two weeks away Pryor is desperate to be at his son's hospital bedside.
Ex-OSS operative Larry Brennan returns to Czechoslovakia after retiring from his military service during World War II. He is intent on seeking out a hidden cache of Nazi jewels stashed in this country during the war. There he has to join with Hedi von Hartmann, his former lover and a daughter of the German general who previously owned the gems, but Larry is not sure whether he can trust her.
The week of Christmas, Rebecca Hodges is frightened in her home one night when she sees someone in a mask depicting a woman's face has broken in and has been watching her in the dark. After being chased briefly, her parents Sam and Joyce are woken up before the intruder smashes their kitchen window with a Christmas decoration before running away. They call the police and after finding nothing, they agree to check up on them for the time being routinely.
After his girlfriend leaves him, lonely horror movie buff Adam Waltz moves to Los Angeles to be closer to her. There he lands a walk-on role in studio chief Connor Pritchett's latest cinematic schlockfest, Pirate Wench. One night, a killer starts stalking the set, and before long bodies are piling up.
A man is watching a television report on the "Cigarette Butt serial Killer" when he is taken hostage by a mysterious figure wearing a yellow jumper. Later, he is found by a highway, disheveled and wearing a yellow jumper, and is rescued by an off-duty cop, who is driving an elderly crime witness (who is implied to be connected with the Cigarette Butt Serial Killer case) to a police station back in the city. The man tells his story: he was captured and tortured by two female religious extremists for a political cartoon, but managed to escape after stealing their shotgun and killing one of his captors.
Nightclub singer Ilona Vance is accused of murder because she was the last person to see crooked attorney Frank Hobart alive. Lt. Hargis attempts to prove her innocence.